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He higher susceptibility of PRSP than PSSP to DM3. This is essentially one of our main objectives in designing DM3 ?a novel drug possessing high antibacterial activity against the antibiotic-resistance strains. The gene expression profile of SP17 (PRSP strain used in this study) was heavily affected by DM3 and DM3PEN which was in sharp contrast to the gene expression profile of SP27 (PSSP strain
Ted in Table 3. Only two individuallevel characteristics were associated with binge drinking: White race/ethnicity and having completed at least some college or university (p
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GO:0019438) biosynthesis processes. Although the differentially expressed genes encoded for a number of amino acids were reported including glycine, alanine, glutamate, and aspartate, the aromatic and branched chain family amino acids were most affected. The branched chain amino acids were valine, leucine, and isoleucine while aromatic amino acids included phenylalanine, tyrosine, and tryptophan.
N transporter CglA while ccs4 and ccs16 are competence-induced proteins. Competence regulation was not the primary target of DM3 in standalone or in combination with PEN. Of note, CoiA, which functions to promote genetic recombination during transformation45, was only found in cells treated with DM3PEN suggesting the unique effect of the synergistic treatment in enhancing transformational recombi

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