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ten.5 and 11.five, followed by evaluation at E14.five (E ). E13.five Gata2LEC embryos exhibit striking edema (C, arrow) and considerably enlarged, blood-filled jugular lymph sacs (arrowhead, C and D), compared with manage littermates (Cre-negative; Gata2fl/fl, A and B). At E14.five, Gata2LEC embryos exhibit edema (I, arrow). Immunostaining of coronal E14.5 tissue sections demonstrated no obvious
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Is still the most lethal gynecologic malignancy worldwide. Although most ovarian carcinoma cells are initially sensitive to chemotherapy, there is always a small population cells that always survives and initiates new tumors which causes recurrence [31]. The verification of tumor heterogeneity further enhances the hypothesis of CSCs. Compelling evidence has shown that ovarian carcinomas with enri
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