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With thirty years of real estate development expertise, Sanford understands how sensitive design management preserves and enhances an area. After purchasing the land in 1998 from the Chandler family, who held the property since 1920’s, Sanford set out to design a community that would transform a site that had fallen into total disrepair. The goal was to maintain the spirit of The Headlands, prese
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I live in Colorado and feel fortunate to have both my grown sons live nearby. My first thirty years were spent in Washington, D.C. where relatives and family friends customarily had their own conspiracy theory about what really happens in government. As an only child, I read a lot and by high school, wanted to become a spy for CIA. I never applied, but instead read loads of book on the topic. Wit
discovered that use oxidative thiol chemistry to regulate their protein activity.This strategy is capable of supplying a global snapshot of your redox state of protein cysteines throughout regular and oxidative stress conditions inside the cell. To detect proteins which have the ability to undergo stress-induced thiol modifications, Leichert and Jakob differentially labeled the thiol groups of th
Ficiently disseminate to mucosal tissues (39, 54). Moreover, the recent demonstration of therapeutic efficacy of a human papilloma virus vaccine delivered by DNA or electroporation in a Phase IIB randomized study in humans (557) demonstrates the efficacy of a pDNA platform in inducing mucosal T cell responses in humans. This delivers the possibility of applying a pDNA vaccination targeting the CE
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Obscured by the blood-brain barrier (BBB) and peripheral immune components. Making use of transgenic mice, which express green fluorescent protein (GFP) in oligodendrocytes and myelin, allowed us to straight monitor demyelination in living OSC. Previously, we had demonstrated the usefulness of this model for the live imaging evaluation of diverse immune effector mechanisms deemed relevant in CNS

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