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Rder, and manic symptoms. Secondary Analyses When controlling for youth's gender, the significance of the main effects of ODD group for co-occurring psychiatric symptoms did not change. When covarying ODD symptom severity using the same informant as was used to define subgroups, several main effects of ODD group remained significant, consistent with the idea that AIS and NS are qualitatively diff
Istent with two-hit genetic models for various diseases, which indicate that differentially greater severity may actually indicate unique pathogenic processes.29 Findings also raise questions regarding the ODD diagnosis, given that youth meeting the 3-symptom criteria for AIS would not meet DSM criteria for ODD without a fourth symptom. However, the results of previous work30,31 indicate that you
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Lder group). As noted above, these secondary analyses were not conducted with the background variables because of the nonparametric nature of these data.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptDiscussionRecent evidence suggests that different types of ODD symptoms have distinct correlates and outcomes,6?2 which in part contributed to a suggestion by the DSM-5 ADH
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Gnosis of ODD with fewer than 4 ODD symptoms. Nevertheless, all youth with 3 AIS also exhibited at least one NS in the present sample. Given that the DSM model may under-identify youth with impairing ODD,30,31 future research should evaluate the prevalence of youth with AIS who do not meet criteria for ODD, as well as multiple models for considering ODD symptoms and diagnoses (e.g., DSM, ICD). Ac
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